Korean Red Ginseng shown to reduce the production of stress hormone – Eight-week trial

By Tingmin Koe

- Last updated on GMT

Red ginseng is commonly consumed in South Korea as a health functional food. ©Getty Images
Red ginseng is commonly consumed in South Korea as a health functional food. ©Getty Images

Related tags korean red ginseng ginsenosides stress

Supplementation with Korean Red Ginseng could reduce the production of the stress hormone cortisol, according to the findings of an eight-week RCT conducted among 90 men who reported being under stress.

Participants who took Korean Red Ginseng also shown a lower reduction in the “happy” hormone serotonin.

The study was conducted by researchers from Korea University Anam Hospital, Yonsei University College of Medicine, and local firm Theragen Health Co. Ltd. Findings were published in the Journal of Ginseng Research.

During the eight-week randomised, double-blind, placebo-controlled trial, 90 healthy men aged 35 to 60 were randomised to take four tablets of either Korean Red Ginseng or the placebo each day.

Korean Red Ginseng contains various active components known as ginsenosides, including Rb1, Rb2, Rg3, Rg1, Rc, Rf, Re, and Rd.

The participants’ stress response was evaluated using the Stress Response Inventory (SRI), a self-administered questionnaire for assessing the response to stress, such as their levels of tension, aggression, anger, depression, and frustration.  

The higher the scores, the more severe was the stress response.

Blood samples were also taken to measure the changes in the participants’ neurotransmitters and hormone levels.

Findings showed that in the face of stressful situations, both the intervention and placebo groups had a reduction in serotonin levels.

However, the reduction was significantly much more in the placebo group than the intervention group, with the former showing a reduction of 6128.2 ± 7547.8 and the latter 3803.2 ± 6610.5.

Cortisol, the stress hormone, also increased in both groups, but the increase in the intervention group was significantly lower than the placebo group.

In addition, adrenaline, the hormone produced during stressful as a “fight or flight” response, had reported a statistically significant decrease in the intervention group as compared to the placebo group.

Adrenaline is also known as epinephrine.

“This is consistent with a previous study showing that KRG (Korean Red Ginseng) can stabilise the sympathetic nervous system by reducing epinephrine for individuals with high stress levels,” said the researchers.

Despite the differences in cortisol and serotonin changes, both groups reported a decrease in SRI, which the researchers said could be a result of placebo effect.

“This study, which was the first to confirm the effect of KRG on stress-related NTs (neurotransmitters) in the general population, is consistent with previous results from in vitro and animal studies, as well as studies on specific occupational groups of humans, which showed some NT effects.

“Thus, this study will be the basis of understanding of the potential anti-stress effect of KRG,” ​said the researchers.

Korean Red Ginseng (KRG) is the most popular health functional food​ in South Korea. A recent study also found that it could increase the production of antibodies​ post-COVID-19 vaccination.


Source: Journal of Ginseng Research

The effects of Korean Red Ginseng on stress-related neurotransmitters and gene expression: A randomized, double-blind, placebo-controlled trial


Authors: Jihyun Yoon, Byoungjin Park, Kyung-Won Hong, Dong-Hyuk Jung

Related news

Related products

show more

Empowering Women Through the Life Cycle

Empowering Women Through the Life Cycle

Content provided by Glanbia Nutritionals | 07-Nov-2023 | Product Brochure

As discussions around female empowerment widen, and advances in women’s health access and provision accelerate, the implications for business, healthcare,...

Analyzing the unknown threat from Microplastics

Analyzing the unknown threat from Microplastics

Content provided by Agilent Technologies | 06-Nov-2023 | Infographic

Microplastics are any plastic-derived synthetic solid particle or polymeric matrix, ranging in size from 1 µm to 5 mm and insoluble in water.

Pycnogenol® Supports Cognitive Function

Pycnogenol® Supports Cognitive Function

Content provided by Horphag Research | 18-Sep-2023 | White Paper

Clinical research shows daily supplementation with Pycnogenol® may help support brain function in a variety of age groups with results showing improved...

Functional Beverage Market Insights in ASPAC

Functional Beverage Market Insights in ASPAC

Content provided by Glanbia Nutritionals | 06-Jul-2023 | Product Brochure

High growth ahead for protein beverages makes Asia Pacific (ASPAC) the market to watch. Consumer research shows new usage occasions, key consumption barriers,...

Related suppliers

Follow us


Food & Beverage Trailblazers

F&B Trailblazers Podcast