The man developed symptoms of AI, such as fever and having respiratory problems, on 10 August and was hospitalised five days later.
He is now in a serious condition and had contact with live poultry before the symptoms started, according to the Centre for Health Protection.
The Centre for Health Protection has urged the public to maintain strict personal, food and environmental hygiene, both locally and for those travelling to the Guangxi area.
Travellers to China and other affected areas have been advised to avoid visiting wet markets, live poultry markets or farms and to be alert to the presence of backyard poultry.
Those returning from China, who develop any sort of AI symptoms, have been urged to inform a doctor about their travel history and whether they have been in contact with poultry.
The Centre for Health Protection has also put control measures in place to prevent the spreading of the disease and will work closely with the World Health Organization and other health authorities to monitor the latest developments.
According to the Centre for Health Protection, there have been 20 human cases of AI H5N6 reported by China’s health authorities since 2014.
China was recently hit with its first case of African Swine Fever, which led to the temporary closure of WH Group’s Zhengzhou facility following 30 hogs being found dead and subsequently detected with the disease.